HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 23445160, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3-Chloro-4-fluoroaniline | HCID 9708 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | Ethyl nitroacetate | HCID 69379 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 23445160 | HCID 23445160 | — |
Reaction Steps
3-Chloro-4-fluoroaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The isolated acid was directly reduced with BH3 THF complex followed by hydrolytic workup and the title compound, Mp. 130-135° C. (H2O), MS: m/e=226 (M+), was obtained as an off-white crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683097B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-89e65923f71d4b9687b8380206b7d42f |
| Source note | uspto-grants-2004_01 |