Thionyl Chloride → 4-Chloromethyl-2-(3,4-dichloro-phenyl)-pyridine hydrochloride

HRID 1841227Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([CH2:15]O)[CH:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].S(Cl)([Cl:19])=O>>[ClH:1].[Cl:19][CH2:15][C:13]1[CH:12]=[CH:11][N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH:14]=1

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 23445072[2-(3,4-Dichlorophenyl)pyridin-4-yl]methanol

Product 1

HCID 234450104-Chloromethyl-2-(3,4-dichloro-phenyl)-pyridine hydrochloride

Procedure

The title compound, MS: m/e=271.0 (M+) was obtained as a light brown foam (100% yield) by the reaction of [2-(3,4-dichloro-phenyl)-pyridine-4-yl]-methanol with thionyl chloride at 20° C. for 1 h.

Sources & evidence

ORD record: ord-2bc52896c9f44fc0bc539225491abea4
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06683097B2

Reaction notes

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