HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → [2-(3,4-Dichlorophenyl)pyridin-4-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2-(3,4-Dichloro-phenyl)-isonicotinic acid methyl ester | HCID 69040624 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [2-(3,4-Dichlorophenyl)pyridin-4-yl]methanol | HCID 23445072 | — |
Reaction Steps
The title compound, MS: m/e=252.0 ([M−H]−) was obtained as a light yellow solid (53% yield) by the reaction of 2-(3,4-dichloro-phenyl)-isonicotinic acid methyl ester with lithium aluminum hydride in THF at 20° C. for 1 h followed by chromatography [silica, elution with CH2Cl2/(2M NH3 MeOH)=19:1]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683097B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-9fff50b446724991bf53f5eff4251241 |
| Source note | uspto-grants-2004_01 |