Aluminium lithium hydride → HCID 23445069, compound

HRID 1841269Notes

Reaction equation

HRID 1841269 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[N:12]=[CH:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]=1)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[C:11]([N:9]2[CH:10]=[C:6]([CH2:4][OH:3])[N:7]=[CH:8]2)[N:12]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 69038871HCID 69038871, compound

Product 1

HCID 23445069HCID 23445069, compound

Procedure

Following the general method described in example 298, 1-isoquinolin-3-yl-1H-imidazole-4-carboxylic acid ethyl ester was reacted with lithium aluminum hydride followed by hydrolytic workup and chromatography. The title compound was obtained as an off-white waxy solid. MS: m/e=226 (M+H+).

Sources & evidence

ORD record
ord-6c144b3f6a0147e2b3f893fc0f909c8c
Source dataset
uspto-grants-2004_01
Patent number
US06683097B2

Reaction notes

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