Sodium Hydroxide → HCID 9910452, compound

Participants

Reaction Steps

Ethyl 3-{4-[2-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-ethoxy]-phenyl}-2-ethoxy-propionate (2.3 g, 53.7 mmol) was dissolved in ethanol (25 ml), 15% sodium hydroxide (7 ml) was added, and the mixture stirred at room temperature for 3 h and stood overnight. The solution was evaporated, water (30 ml) added to the residue, and the mixture acidified to pH 6 with acetic acid (1.6 ml). The product was extracted with dichloromethane (3×20 ml), and the dichloromethane solution washed with water (20 ml), brine (20 ml), dried (MgSO4) and evaporated. The residue was crystallised from a mixture of toluene (8 ml) and n-heptane (8 ml) to give the title compound; 1.60 g (74.4%).

Provenance & Evidence