反应详情

The title compound was prepared according to the procedure in Example 5, step 3 using (2-benzyl-4,5-dimethyl-furan-3-yl)-(3,5-diethyl-4-methoxy-phenyl)-methanone (19.3 g, 51.2 mmol) and 1M boron tribromide/CH2Cl2 (36.8 mL) in CH2Cl2. Purification on Biotage KP-Sil eluting with a 2 & 5% EtOAc/hexane step gradient gave 7.07 g (37%) of the title compound. 1H NMR (DMSO-d6) δ1.08 (t, 6 H), 1.79 (s, 3 H), 2.17 (s, 3 H), 2.57 (q, 4 H), 3.81 (s, 2 H), 7.06 (dd, 2 H), 7.16-7.18 (m, 1 H), 7.22-7.26 (m, 2 H), 7.37 (s, 2 H), 9.10 (s, 1 H). mass spectrum (EI), m/z 362 (M+).

1. customThe title compound was prepared
2. customPurification on Biotage KP-Sil
3. washeluting with a 2 & 5% EtOAc/hexane step gradient