2-Hydroxy-5-methylacetophenone → HCID 23444713, compound

HRID 1841359Notes

Reaction equation

HRID 1841359 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([CH3:11])=[O:10])[CH:3]=1.[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][C:21]=1[N+:28]([O-:30])=[O:29])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[CH:27]=[CH:26][C:23](/[CH:24]=[CH:11]/[C:9]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=2[OH:8])=[O:10])=[CH:22][C:21]=1[N+:28]([O-:30])=[O:29])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 150682-Hydroxy-5-methylacetophenoneHCID 70235544-(Benzyloxy)-3-nitrobenzaldehyde

Product 1

HCID 23444713HCID 23444713, compoundYield 32.1%

Procedure

2-Hydroxy-5-methylacetophenone (200 mg, 1.33 mol) and 4-benzyloxy-3-nitrobenzaldehyde (350 mg, 1.36 mmol) were reacted according to the same procedure as Preparation 1 to give 170 mg (Yield 29%) of the title compound.

Workup

  1. customaccording to the same procedure as Preparation 1

Sources & evidence

ORD record
ord-80420fce35d44f78b3b0e9f1732480e7
Source dataset
uspto-grants-2004_01
Patent number
US06683095B2

Reaction notes

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