Acetic Anhydride → HCID 9858456, compound

HRID 1841360Notes

Reaction equation

HRID 1841360 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:20])[C:18]=2[OH:19])=[CH:15][C:14]([CH3:21])=[CH:13][CH:12]=3)[CH:5]=[CH:6][C:7]=1[OH:8].[C:22](OC(=O)C)(=[O:24])[CH3:23]>ClCCl>[OH:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]2[O:10][C:11]3[C:16]([C:17](=[O:20])[C:18]=2[OH:19])=[CH:15][C:14]([CH3:21])=[CH:13][CH:12]=3)=[CH:3][C:2]=1[NH:1][C:22](=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 9965595HCID 9965595, compound

Product 1

HCID 9858456HCID 9858456, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound prepared in Example 5 (10 mg, 35 μmol) was dissolved in dichloromethane (2 ml) and reacted with excess acetic anhydride for 1 hour at room temperature. The mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: 50% ethylacetate/hexane) to give 5 mg (Yield 44%) of the title compound.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by silica gel column chromatography (eluent: 50% ethylacetate/hexane)

Sources & evidence

ORD record
ord-f7718b8ea0414cbeba1f2e0456783c4b
Source dataset
uspto-grants-2004_01
Patent number
US06683095B2

Reaction notes

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