2-Hydroxy-5-methylacetophenone → (e)-3-[2-(Benzyloxy)-3,4-dimethoxyphenyl]-1-(2-hydroxy-5-methylphenyl)-2-propen-1-one

HRID 1841362Notes

Reaction equation

HRID 1841362 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([CH3:11])=[O:10])[CH:3]=1.[CH2:12]([O:19][C:20]1[C:27]([O:28][CH3:29])=[C:26]([O:30][CH3:31])[CH:25]=[CH:24][C:21]=1[CH:22]=O)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([O:19][C:20]1[C:27]([O:28][CH3:29])=[C:26]([O:30][CH3:31])[CH:25]=[CH:24][C:21]=1/[CH:22]=[CH:11]/[C:9]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:7]=[CH:6][C:5]=1[OH:8])=[O:10])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 150682-Hydroxy-5-methylacetophenoneHCID 8195792-(Benzyloxy)-3,4-dimethoxybenzaldehyde

Product 1

HCID 23444723(e)-3-[2-(Benzyloxy)-3,4-dimethoxyphenyl]-1-(2-hydroxy-5-methylphenyl)-2-propen-1-oneYield 76%

Procedure

2-Hydroxy-5-methylacetophenone (690 mg, 2.53 mmol) and 2-benzyloxy-3,4-dimethoxybenzaldehyde (460 mg, 3.03 mmol) was reacted according to the same procedure as Preparation 1 to give 740 mg (Yield 76%) of the title compound.

Workup

  1. customaccording to the same procedure as Preparation 1

Sources & evidence

ORD record
ord-a97ebd4fa6674d24af7762740780da48
Source dataset
uspto-grants-2004_01
Patent number
US06683095B2

Reaction notes

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