3-Chloro-4-fluorobenzaldehyde → HCID 23444768, compound

HRID 1841367Notes

Reaction equation

HRID 1841367 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]([CH3:10])=[O:9])[C:5]([OH:11])=[C:4]([N+:12]([O-:14])=[O:13])[CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][C:23]=1[F:24])[CH:19]=O>>[Cl:15][C:16]1[CH:17]=[C:18](/[CH:19]=[CH:10]/[C:8]([C:6]2[CH:7]=[C:2]([CH3:1])[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]=2[OH:11])=[O:9])[CH:21]=[CH:22][C:23]=1[F:24]

Participants

3

Reactant 2

HCID 5938663-Chloro-4-fluorobenzaldehydeHCID 7361622'-Hydroxy-5'-methyl-3'-nitroacetophenone

Product 1

HCID 23444768HCID 23444768, compoundYield 94%

Procedure

2-Hydroxy-5-methyl-3-nitroacetophenone (500 mg, 2.56 mmol) and 3-chloro-4-fluorobenzaldehyde (486 mg, 3.07 mmol) were reacted according to the same procedure as Preparation 22 to give 800 mg (Yield 94%) of the title compound.

Workup

  1. customaccording to the same procedure as Preparation 22

Sources & evidence

ORD record
ord-5fafeda195c4430a9993bbca30908afb
Source dataset
uspto-grants-2004_01
Patent number
US06683095B2

Reaction notes

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