Sulfuryl chloride → HCID 23445551, compound

HRID 1841397Notes

Reaction equation

HRID 1841397 reaction equation
[CH2:1]1[O:24][C:23]2[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][C:8]3[S:9][CH:10]=[CH:11][C:12]=3[S:13](N3C=CC=C3)(=[O:15])=[O:14])=[CH:4][C:3]=2[O:2]1.[K].S(Cl)([Cl:29])(=O)=O>>[Cl:29][S:13]([C:12]1[CH:11]=[CH:10][S:9][C:8]=1[CH2:7][CH2:6][C:5]1[CH:21]=[CH:22][C:23]2[O:24][CH2:1][O:2][C:3]=2[CH:4]=1)(=[O:15])=[O:14]

Participants

4

Reactant 3

HCID 24648Sulfuryl chlorideHCID 5462222PotassiumHCID 23445359HCID 23445359, compound

Product 1

HCID 23445551HCID 23445551, compoundYield 42%

Procedure

3-chlorosulfonyl-2-[3,4-(methylenedioxy)phenethyl]thiophene was prepared in the same manner as described in the Example 1 5E using N-{2-[3,4-(methylenedioxy)phenethyl]thiophene-3-sulfonyl}pyrrole by conducting basic hydrolysis (iso-propanol and potassium hydroxide) of the sulfonamide to the potassium salt of sulfonic acid (93%) followed by conversion of the salt to the corresponding sulfonyl chloride in a 42% yield.

Sources & evidence

ORD record
ord-e6d52d5624974c7ab8490d0271e6dcb9
Source dataset
uspto-grants-2004_01
Patent number
US06683103B2

Reaction notes

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