4-Bromo-3-methylisoxazol-5-amine → HCID 23445430, compound

HRID 1841399Notes

Reaction equation

HRID 1841399 reaction equation
[CH3:1][C:2]1[CH:18]=[CH:17][C:5](/[CH:6]=[CH:7]/[C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13](Cl)(=[O:15])=[O:14])=[CH:4][CH:3]=1.[NH2:19][C:20]1[O:24][N:23]=[C:22]([CH3:25])[C:21]=1[Br:26]>>[Br:26][C:21]1[C:22]([CH3:25])=[N:23][O:24][C:20]=1[NH:19][S:13]([C:12]1[CH:11]=[CH:10][S:9][C:8]=1/[CH:7]=[CH:6]/[C:5]1[CH:17]=[CH:18][C:2]([CH3:1])=[CH:3][CH:4]=1)(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 23445281HCID 23445281, compound

Product 1

HCID 23445430HCID 23445430, compoundYield 34%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-2-(4-methyl-trans-styryl)thiophene-3-sulfonamide was prepared in the same manner as described in Example 10 by reaction of 2-(4-methyl-trans-styryl)thiophene-3-sulfonyl chloride with 5-amino-4-bromo-3-methylisoxazole. The crude product was purified by HPLC followed by crystallization resulting in a 34% yield, m.p. 101-105° C.

Workup

  1. customThe crude product was purified by HPLC
  2. customfollowed by crystallization
  3. customresulting in a 34% yield, m.p. 101-105° C.

Sources & evidence

ORD record
ord-1d7a064cc6d14a72b5ec02a000f00ade
Source dataset
uspto-grants-2004_01
Patent number
US06683103B2

Reaction notes

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