Ammonia → HCID 13479938, compound
Reaction equation
[NH3:1].Cl[C:3]1[N:4]=[C:5]([S:14][CH3:15])[N:6]=[N:7][C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]>>[NH2:1][C:3]1[N:4]=[C:5]([S:14][CH3:15])[N:6]=[N:7][C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10]Participants
3
Procedure
can be prepared if ammonia is used to displace the chloro group of 5-chloro-3-methylsulfanyl-1,2,4-triazine-6-carboxylic acid, ethyl ester to give 5-amino-3-methylsulfanyl-1,2,4-triazine-6-carboxylic acid, ethyl ester. The aldehyde is obtained and reacted with a substituted phenyl acetonitrile as described above to provide the 6-amino-pyridotriazines. The methylthio group is displaced as described above, also, and the 6-amino group of the resulting 6-amino-7-substituted phenyl-3-substituted amino-pyrido-1,2,4-triazine is derivatized by standard methods, for example alkylation or acylation, to provide compounds of Formula III.
Sources & evidence
- ORD record
- ord-30548bcf453240c29c9a4e0b83c3c4de
- Source dataset
- uspto-grants-2004_01
- Patent number
- US06683183B2
Reaction notes
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