HCID 12098505, compound → HCID 10182659, compound

Participants

Reaction Conditions

Reaction Steps

To 300 mg (0.84 mmol) of 7-(3,5-dimethoxy-phenyl)-5-ethyl-3-methylsulfanyl-5H-pyrido[2,3-e]-1,2,4-triazin-6-one was added 1.25 g (8.7 mmol) of N,N-diethylaminobutylamine. The reaction mixture was warmed at 70° C. for 1.5 hours and cooled to room temperature. A seed crystal was added to the solution, and it was set overnight. The resulting crystalline material was collected, washed with 1:1 diethyl ether/hexane and dried under house vacuum to give 318 mg (83%) of the title compound as pale yellow solid. Mp=120-121° C.(dec); when placed in a 119° C. melting point apparatus. MS (APCI) (m+1)/z 455.2.

Provenance & Evidence