1-(3,5-Dimethoxyphenyl)piperazine → 1-[(5,6-Dimethyl-2-methoxypyrazin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazine

HRID 1841449Notes

Reaction equation

HRID 1841449 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:11][C:12](=[O:20])OC2C=CC=CC=2)[C:5]([O:9][CH3:10])=[N:6][C:7]=1[CH3:8].[CH3:21][O:22][C:23]1[CH:24]=[C:25]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:26]=[C:27]([O:29][CH3:30])[CH:28]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:11][C:12]([N:34]2[CH2:33][CH2:32][N:31]([C:25]3[CH:24]=[C:23]([O:22][CH3:21])[CH:28]=[C:27]([O:29][CH3:30])[CH:26]=3)[CH2:36][CH2:35]2)=[O:20])[C:5]([O:9][CH3:10])=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 27362051-(3,5-Dimethoxyphenyl)piperazineHCID 11173351Phenyl N-(5,6-dimethyl-2-methoxypyrazin-3-yl)carbamate

Product 1

HCID 234463451-[(5,6-Dimethyl-2-methoxypyrazin-3-yl)aminocarbonyl]-4-(3,5-dimethoxyphenyl)piperazineYield 85%

Procedure

Phenyl N-(5,6-dimethyl-2-methoxypyrazin-3-yl)carbamate and 1-(3,5-dimethoxyphenyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound.

Sources & evidence

ORD record
ord-ef0223b3e6b0468e9bff5f4149538325
Source dataset
uspto-grants-2004_01
Patent number
US06683184B2

Reaction notes

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