1-(3,5-Dichlorophenyl)piperazine → 1-[(5,6-Dimethyl-2-methoxypyrazin-3-yl)aminothiocarbonyl]-4-(3,5-dichlorophenyl)piperazine

HRID 1841467Notes

Reaction equation

HRID 1841467 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:11][C:12](=[S:20])OC2C=CC=CC=2)[C:5]([O:9][CH3:10])=[N:6][C:7]=1[CH3:8].[Cl:21][C:22]1[CH:23]=[C:24]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:25]=[C:26]([Cl:28])[CH:27]=1>>[CH3:1][C:2]1[N:3]=[C:4]([NH:11][C:12]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:23]=[C:22]([Cl:21])[CH:27]=[C:26]([Cl:28])[CH:25]=3)[CH2:34][CH2:33]2)=[S:20])[C:5]([O:9][CH3:10])=[N:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 27360671-(3,5-Dichlorophenyl)piperazineHCID 54547361Phenyl N-(5,6-dimethyl-2-methoxypyrazin-3-yl)thiocarbamate

Product 1

HCID 539157141-[(5,6-Dimethyl-2-methoxypyrazin-3-yl)aminothiocarbonyl]-4-(3,5-dichlorophenyl)piperazineYield 70.8%

Procedure

Phenyl N-(5,6-dimethyl-2-methoxypyrazin-3-yl)thiocarbamate and 1-(3,5-dichlorophenyl)piperazine were reacted by the same way with the example 28 to obtain the titled compound.

Sources & evidence

ORD record
ord-4f9d1a9821144b319cf678a9ea95858a
Source dataset
uspto-grants-2004_01
Patent number
US06683184B2

Reaction notes

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