HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → 1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate | HCID 23446261 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[(2-Methoxyquinoxalin-3-yl)aminocarbonyl]-4-phenylpiperazine | HCID 23446310 | 76.5% |
Reaction Steps
Phenyl N-(2-methoxyquinoxalin-3-yl)carbamate (378 mg, 1.28 mmol) and 1-phenylpiperazine (208 mg, 1.28 mmol) were dissolved in anhydrous tetrahydrofuran and thereto DBU (195 mg, 1.28 mmol) was added. The mixture was stirred at room temperature for 2 hours, concentrated under the reduced pressure to remove the solvent, and purified by column chromatography to obtain the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683184B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-e7f5406943b0490c94103ffa25628ee8 |
| Source note | uspto-grants-2004_01 |