1-(3-Bromophenyl)piperazine → 1-[(2-Ethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-bromophenyl)piperazine

HRID 1841501Notes

Reaction equation

HRID 1841501 reaction equation
[CH2:1]([O:3][C:4]1[C:13]([NH:14][C:15](=[O:23])OC2C=CC=CC=2)=[N:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH3:2].[Br:24][C:25]1[CH:26]=[C:27]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:28]=[CH:29][CH:30]=1>>[CH2:1]([O:3][C:4]1[C:13]([NH:14][C:15]([N:34]2[CH2:33][CH2:32][N:31]([C:27]3[CH:28]=[CH:29][CH:30]=[C:25]([Br:24])[CH:26]=3)[CH2:36][CH2:35]2)=[O:23])=[N:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27571541-(3-Bromophenyl)piperazineHCID 23446273Phenyl N-(2-ethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 234463171-[(2-Ethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-bromophenyl)piperazineYield 80.6%

Procedure

Phenyl N-(2-ethoxyquinoxalin-3-yl)carbamate and 1-(3-bromophenyl)-piperazine were reacted by the same way with the example 36 to obtain the titled compound.

Sources & evidence

ORD record
ord-ae0671ca5b4d451e9ea8a504a73a1f24
Source dataset
uspto-grants-2004_01
Patent number
US06683184B2

Reaction notes

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