1-(3,5-Difluorophenyl)piperazine → 1-[(2-Ethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazine

HRID 1841502Notes

Reaction equation

HRID 1841502 reaction equation
[CH2:1]([O:3][C:4]1[C:13]([NH:14][C:15](=[O:23])OC2C=CC=CC=2)=[N:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH3:2].[F:24][C:25]1[CH:26]=[C:27]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:28]=[C:29]([F:31])[CH:30]=1>>[CH2:1]([O:3][C:4]1[C:13]([NH:14][C:15]([N:35]2[CH2:34][CH2:33][N:32]([C:27]3[CH:26]=[C:25]([F:24])[CH:30]=[C:29]([F:31])[CH:28]=3)[CH2:37][CH2:36]2)=[O:23])=[N:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 109872191-(3,5-Difluorophenyl)piperazineHCID 23446273Phenyl N-(2-ethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 234463371-[(2-Ethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3,5-difluorophenyl)piperazineYield 78.6%

Procedure

Phenyl N-(2-ethoxyquinoxalin-3-yl)carbamate and 1-(3,5-difluorophenyl)piperazine were reacted by the same way with the example 36 to obtain the titled compound.

Sources & evidence

ORD record
ord-af642de0cf9d4eec872fe9b8e719d6df
Source dataset
uspto-grants-2004_01
Patent number
US06683184B2

Reaction notes

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