反应详情

2,6-Dibenzoylpyridine (464 mg, 1.61 mmol) and 2,6-difluoroaniline (7.33 mg, 5.67 mmol) were dissolved in 30 ml of toluene. To this solution molecular sieves (4 Å) were added. After standing for 3 days at room temperature (with addition of more molecular sieves after 2 days) the mixture was filtered. The solvent was removed in vacuo. The residue was crystallised from ethanol. Yield 250 mg (30%) of 2,6-bis[(2,6-difluorophenylimino) (phenyl) methyl]pyridine 8 as a mixture of 3 isomers.

1. additionTo this solution molecular sieves (4 Å) were added
2. addition(with addition of more molecular sieves after 2 days) the mixture
3. filtrationwas filtered
4. customThe solvent was removed in vacuo
5. customThe residue was crystallised from ethanol
6. additionYield 250 mg (30%) of 2,6-bis[(2,6-difluorophenylimino) (phenyl) methyl]pyridine 8 as a mixture of 3 isomers