Water → Diethyl 2-({4-[(acetyloxy)methyl]-2-iodoanilino}methylene)malonate

Participants

Reaction Steps

A solution of diethyl 2-{[4-(hydroxymethyl)-2-iodoanilino]methylene}malonate (0.20 g) and acetic anhydride (0.054 mL) in acetic acid (0.24 mL) is heated at 80° C. overnight. The reaction is cooled to room temperature and poured into 50 mL of water. The resulting solid is filtered and dried to yield 0.19 g (87%) of diethyl 2-({4-[(acetyloxy)methyl]-2-iodoanilino} methylene)malonate as a white solid, m.p. 128-131° C.

Provenance & Evidence