反应详情

温度

190 °C

To a flask containing ethyl 4-hydroxy-8-iodo-6-(4-morpholinylmethyl)-3-quinolinecarboxylate of Preparation 25 (3.11 g) is added 4-chlorobenzylamine (8.0 mL). The mixture is degassed under reduced pressure. The mixture is placed under an argon atmosphere and is heated at 190° C. for 3 h. The reaction is cooled to room temperature. The excess benzylamine is removed by high vacuum distillation. The residue is crystallized from acetonitrile:methanol (1:1, 800 mL) to yield 3.08 g of the title compound as a white solid.

1. additionTo a flask containing
2. customThe mixture is degassed under reduced pressure
3. temperatureThe reaction is cooled to room temperature
4. customThe excess benzylamine is removed by high vacuum distillation
5. customThe residue is crystallized from acetonitrile:methanol (1:1, 800 mL)