Indole → HCID 71772328, compound

Participants

Reaction Steps

FIG. 1b shows the synthesis of 5,6,7-trichlorogramine. A solution of indole (AA) in ethanol is added to a solution of sodium bisulfite in water. The mixture is stirred at room temperature for 12 hrs. The solid precipitate is filtered, washed with ether, and dried to yield sodium indole-2-sulfonate (BB) as a white solid. The sodium indole-2-sulfonate product (BB) is used in the next step without further purification. MP>320° C.; IR (KBr, cm−1) 3470, 3250, 1650, 1600, 1490, 1460, 1210, 1170, 1040, 760, 750.

Provenance & Evidence