反应详情

To a cooled (0° C.) solution of 16-hydroxyhexadecanoic acid (3000 mg, 10.79 mmol) in anhydrous methanol (27 ml) acetyl chloride (3.837 ml, 53.96 mmol) was added dropwise at 0° C. within 2 min, then the mixture was stirred at room temperature for 3.5 hrs under Ar-atmosphere. Subsequently the mixture was evaporated to dryness, the residue was dissolved in dichloromethane (100 ml), washed with saturated sodium bicarbonate solution (2×50 ml) and Brine solution (1×50 ml). After drying over sodium sulfate the collected organic layer was evaporated to dryness and vacuum dried at room temperature. Yield: 92% (white solid).

1. additionwas added dropwise at 0° C. within 2 min
2. customSubsequently the mixture was evaporated to dryness
3. dissolutionthe residue was dissolved in dichloromethane (100 ml)
4. washwashed with saturated sodium bicarbonate solution (2×50 ml) and Brine solution (1×50 ml)
5. dry with materialAfter drying over sodium sulfate the collected organic layer
6. customwas evaporated to dryness and vacuum
7. customdried at room temperature