反应详情

Under nitrogen gas, 4.10 g of the compound of Example 2A were suspended in 100 ml of 30% strength aqueous potassium hydroxide solution, and the mixture was stirred at reflux overnight. The mixture was concentrated to about 25% of the volume and, at 0-10° C., adjusted to pH 5.5 using concentrated aqueous hydrogen chloride solution. The solution was concentrated and dried. The residue (4.30 g) was used directly for the esterification.

1. temperatureat reflux overnight
2. concentrationThe mixture was concentrated to about 25% of the volume and, at 0-10° C.
3. concentrationThe solution was concentrated
4. customdried