反应详情

Lindlar's catalyst (0.005 g, 0.001 mmol) was added in one portion to a stirred solution of 4-[4-(1-oxo-but-2-ynylamino)-benzenesulfonyl]-piperazine-1-carboxylic acid tert-butyl ester (0.05 g, 0.11 mmol) in methanol (5 ml) at room temperature, the resulting mixture was then stirred at room temperature under a hydrogen atmosphere for 2 hours. After this time, the reaction mixture was filtered through celite and concentrated under vacuum to give the title compound (0.02 g, 40% yield) as a white solid.

1. filtrationAfter this time, the reaction mixture was filtered through celite
2. concentrationconcentrated under vacuum