Acryloyl chloride → HCID 52939643, compound

Participants

Reaction Steps

[1-(4-Amino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid benzyl ester (1.29 g, 3.3 mmol) was dissolved in DCM (20 ml). To this was added diisopropylethylamine (1.64 ml, 9.9 mmol) in one portion followed by the drop wise addition of acryloyl chloride (0.3 ml, 3.6 mmol) and the mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours. The THF was removed under vacuum and the resulting crude material was purified by Prep HPLC to give the title compound (10.4 mg, 1% yield) as a white powder.

Provenance & Evidence