Benzyl isocyanate → HCID 27533560, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(4-Nitro-benzenesulfonyl)-piperazine (1.0 g, 2.6 mmol) in pyridine (10 ml) was added benzyl isocyanate (0.35 ml, 2.85 mmol) in one portion. The resulting mixture was then heated at 50° C. for 2 hours before being cooled to room temperature and concentrated under vacuum. The resulting residue was dissolved in ethyl acetate (50 ml) and washed with 1M HCl (100 ml), the organic layer was separated, dried (MgSO4), filtered and concentrated under vacuum to give the title compound (0.5 g, 47% yield) as a yellow solid which was used without further purification. Tr=1.86 min, m/z (ES+) (M+H)+ 405.

Provenance & Evidence