Acryloyl chloride → HCID 67194447, compound

Participants

Reaction Steps

4-(4-Amino-benzenesulfonyl)-piperazine-1-carboxylic acid benzylamide (0.47 g, 1.25 mmol) was dissolved in DMF (10 ml). To this was added diisopropylethylamine (0.33 ml, 1.9 mmol) in one portion followed by the drop wise addition of acryloyl chloride (0.12 ml, 1.5 mmol) and the mixture was stirred at room temperature under a nitrogen atmosphere for 3 hours. The THF was removed under vacuum and the resulting crude material was purified by column chromatography (elution: 50% heptane, 50% ethyl acetate to 100% ethyl acetate) to give the title compound (54 mg, 10% yield) as a white solid.

Provenance & Evidence