Ammonium Hydroxide → HCID 57459596, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound D1 (8 g, 29.21 mmol) in 1,4-dioxane (450 ml), was added hydrazine monohydrate (14.169 ml, 175.255 mmol). The reaction mixture was heated in a sealed tube at 70° C. for 16 h. After cooling, NH4OH (32% aqueous solution) was added and the resulting mixture was concentrated in vacuo. The white solid residue thus obtained was taken up in EtOH to obtain a suspension which was heated and filtered. The filtrate was cooled and the precipitate thus obtained was filtered off. The resulting filtrate was concentrated in vacuo to yield intermediate compound D2 (2.67 g, 52%) as a white solid.

Provenance & Evidence