4-(N-Boc-amino)piperidine → 1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-ylamine

HRID 1841974Notes

Reaction equation

HRID 1841974 reaction equation
[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[O:4][C@@H:3]([C:11]2[CH:18]=[CH:17][C:14]([CH:15]=O)=[CH:13][CH:12]=2)[CH2:2]1.C(OC(=O)[NH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)(C)(C)C>>[O:1]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[O:4][C@@H:3]([C:11]2[CH:18]=[CH:17][C:14]([CH2:15][N:29]3[CH2:30][CH2:31][CH:26]([NH2:25])[CH2:27][CH2:28]3)=[CH:13][CH:12]=2)[CH2:2]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 86696106(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzaldehyde

Product 1

HCID 866953541-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-ylamine

Procedure

Intermediate M is prepared from Intermediate C and Piperidin-4-yl-carbamic acid tert-butyl ester according to Example 217.

Sources & evidence

ORD record
ord-40ffcb120e53409cadf6214afe9ee183
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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