HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1841978Generated: October 29, 2026
Hydrochloric Acid → 4-Methylpiperidin-4-ol hydrochloride
https://huagongshe.com/reaction/1841978
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-Boc-4-methyl-piperidin-4-OL | HCID 22730812 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Methylpiperidin-4-ol hydrochloride | HCID 21949295 | — |
Reaction Steps
To a solution of 4-hydroxy-4-methyl-piperidine-1-carboxylic acid tert-butyl ester (1.08 g, 4.87 mmol) in DCM (25 mL) is added 4M HCl in 1,4-dioxane (20 mL, 80 mmol) and the reaction stirred at about 25° C. for 18 hours. The reaction is concentrated, suspended in Et2O and heptane, and filtered to afford the title compound (R) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946203B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-918be3427e3e4141b713aa760ad196bf |
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| Source note | uspto-grants-2015_02 |
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