HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1841980Generated: November 1, 2026
Hydrochloric Acid → 1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride
https://huagongshe.com/reaction/1841980
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Tert-butyl 3-acetyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | HCID 86695356 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride | HCID 67205682 | — |
Reaction Steps
To a solution of 3-acetyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (1.20 g, 4.49 mmol) in DCM (25 mL) is added 4M HCl in 1,4-dioxane (20.0 mL, 80.0 mmol) and the reaction stirred at about 25° C. for 18 hours. The reaction is concentrated, suspended in Et2O, and filtered to afford the title compound (U) as a hydroscopic solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946203B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-86f155177b3c4d1faf0382b932cf5a35 |
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| Source note | uspto-grants-2015_02 |
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