HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane → (S)-3-{4-[(1S,4S)-1-(2,5-Diaza-bicyclo[2.2.1]hept-2-yl)methyl]-phenyl}-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane | HCID 11521263 | — |
| Reactant | (S)-3-(4-piperazin-1-ylmethyl-phenyl)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine | HCID 86695358 | — |
| Reactant | 4-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 86695362 | — |
| Product | (S)-3-{4-[(1S,4S)-1-(2,5-Diaza-bicyclo[2.2.1]hept-2-yl)methyl]-phenyl}-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine | HCID 86695361 | — |
Reaction Steps
The title product NN is prepared from NN-1 (prepared from Intermediate C and (1S,4S)-2,5-Diaza-bicyclo[2.2.1]-heptane-2-carboxylic acid tert-butyl ester according to General Method N) according to the procedure for synthesis of Intermediate S.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946203B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-2841d6632b804a4fb987f76c518bbe9a |
| Source note | uspto-grants-2015_02 |