HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride → 1-{8-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-3,8-diaza-bicyclo[3.2.1]oct-3-yl}-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride | HCID 67205682 | — |
| Reactant | 4-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 86695362 | — |
| Product | 1-{8-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-3,8-diaza-bicyclo[3.2.1]oct-3-yl}-ethanone | HCID 71735090 | — |
Reaction Steps
Compound 271 is synthesized from Intermediate C and Intermediate U according to General Method H. (LC/MS method 16: ES+ m/z 380.5 [M+H]+, Rt=2.52 min)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946203B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c7651fc4c9314d918a828b11b6f6211e |
| Source note | uspto-grants-2015_02 |