1,4-Thiazepane-1,1-dione hydrochloride → HCID 71735093, compound

HRID 1842014Notes

Reaction equation

HRID 1842014 reaction equation
C(OC(N1CC[N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[S:31]1(=[O:39])(=[O:38])[CH2:37][CH2:36][CH2:35]NCC1>>[O:38]=[S:31]1(=[O:39])[CH2:37][CH2:36][CH2:35][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 457925881,4-Thiazepane-1,1-dione hydrochlorideHCID 866953624-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71735093HCID 71735093, compound

Procedure

Compound 275 is synthesized from Intermediate C and [1,4]thiazepane 1,1-dioxide according to General Method H. (LC/MS method 16: ES+ m/z 375.4 [M+H]+, Rt=2.51 min)

Sources & evidence

ORD record
ord-7a2387b72aa84d62bb71f6d4073578d7
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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