4-Methylpiperidin-4-ol hydrochloride → HCID 71735244, compound

HRID 1842015Notes

Reaction equation

HRID 1842015 reaction equation
C(OC(N1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.[CH3:32][C:33]1([OH:39])CCNCC1>>[O:23]1[C:24]2[C:25](=[N:26][CH:27]=[CH:28][CH:29]=2)[O:30][C@@H:21]([C:18]2[CH:19]=[CH:20][C:15]([CH2:14][N:11]3[CH2:12][CH2:13][C:33]([CH3:32])([OH:39])[CH2:9][CH2:10]3)=[CH:16][CH:17]=2)[CH2:22]1

Participants

3

Reactant 2

HCID 219492954-Methylpiperidin-4-ol hydrochlorideHCID 866953624-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71735244HCID 71735244, compound

Procedure

Compound 276 is synthesized from Intermediate C and Intermediate R according to General Method K. (LC/MS method 16: ES+ m/z 341.2 [M+H]+, Rt=2.50 min)

Sources & evidence

ORD record
ord-3a83d0e3d19b4a30921bf0b9e9fb9f59
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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