HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Piperazin-1-yl)acetonitrile → {4-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazin-1-yl}-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Piperazin-1-yl)acetonitrile | HCID 15522031 | — |
| Reactant | Tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate | HCID 21936030 | — |
| Reactant | 1-(3,8-Diaza-bicyclo[3.2.1]oct-3-yl)-ethanone hydrochloride | HCID 67205682 | — |
| Reactant | 4-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 86695362 | — |
| Product | {4-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazin-1-yl}-acetonitrile | HCID 71735412 | — |
Reaction Steps
Compound 284 is synthesized from Intermediate C and piperazin-1-yl-acetonitrile (prepared from 4-Cyanomethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedure used to synthesize Intermediate U from U-1) according to General Method F. (LC/MS method 16: ES+ m/z 351.3 [M+H]+, Rt=2.68 min)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946203B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-f71454ab77664ab4b083e3b87491b5d9 |
| Source note | uspto-grants-2015_02 |