HCID 27282253, compound → HCID 71735413, compound

HRID 1842019Notes

Reaction equation

HRID 1842019 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C@@H:21]3[O:30][C:25]4=[N:26][CH:27]=[CH:28][CH:29]=[C:24]4[O:23][CH2:22]3)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.C1[C@H]2CNCCN2C(=O)O1>>[O:23]1[C:24]2[C:25](=[N:26][CH:27]=[CH:28][CH:29]=2)[O:30][C@@H:21]([C:18]2[CH:19]=[CH:20][C:15]([CH2:14][N:11]3[CH2:10][CH2:9][N:8]4[C:6](=[O:7])[O:5][CH2:1][C@H:13]4[CH2:12]3)=[CH:16][CH:17]=2)[CH2:22]1

Participants

3

Reactant 2

HCID 27282253HCID 27282253, compoundHCID 866953624-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 71735413HCID 71735413, compound

Procedure

Compound 285 is synthesized from Intermediate C and (R)-hexahydro-oxazolo[3,4-a]pyrazin-3-one according to General Method M. (LC/MS method 16: ES+ m/z 368.4 [M+H]+, Rt=2.52 min).

Sources & evidence

ORD record
ord-8d27429d664b43aca9febed19c43e633
Source dataset
uspto-grants-2015_02
Patent number
US08946203B2

Reaction notes

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