HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Hydroxyazetidine → {1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-yl}-(3-hydroxy-azetidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Hydroxyazetidine | HCID 1514290 | — |
| Reactant | 1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidine-4-carboxylic acid | HCID 68359044 | — |
| Product | {1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-yl}-(3-hydroxy-azetidin-1-yl)-methanone | HCID 71735414 | — |
Reaction Steps
Compound 286 is synthesized from Intermediate K and azetidin-3-ol according to the procedure used to synthesize Example 255. (LC/MS method 16: ES+ m/z 410.4 [M+H]+, Rt=0.35 min)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946203B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-a7ffd599fa354457863cb9e321a58bb6 |
| Source note | uspto-grants-2015_02 |