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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1842022Generated: October 26, 2026

Oxane-4-carboxylic acid → N-[1-[[4-[(3S)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl]phenyl]methyl]-4-piperidyl]tetrahydropyran-4-carboxamide

https://huagongshe.com/reaction/1842022

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOxane-4-carboxylic acidHCID 219302—
Reactant1-[(S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl)-benzyl]-piperidin-4-ylamineHCID 86695354—
ProductN-[1-[[4-[(3S)-2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-3-yl]phenyl]methyl]-4-piperidyl]tetrahydropyran-4-carboxamideHCID 71735575—

Reaction Steps

Compound 290 is synthesized from Intermediate M and Tetrahydro-pyran-4-carboxylic acid according to the procedure used to synthesize Example 261. (LC/MS method 16: ES+m/z 438.4 [M+H]+, Rt=1.44 mM)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08946203B2
Source datasetuspto-grants-2015_02
ORD IDord-c6b2f939247a453189e109562667d5db
Source noteuspto-grants-2015_02