4-Cyanobenzenesulfonyl chloride → 4-[6-(4-Trifluoromethyl-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-benzonitrile

Participants

Reaction Steps

582 mg of commercially available 4-cyano-benzenesulfonyl chloride were dissolved in 5 ml pyridine. Then 400 mg 6-(4-Trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline were added and the mixture was stirred at room temperature for thirty minutes. Then 290 mg of commercially available 4-cyano-benzenesulfonyl chloride were added and the mixture was stirred at room temperature for additional two hours. Then the solvent was removed in vacuo and the residue was purified by chromatography on silica gel to obtain 307 mg of 4-[6-(4-Trifluoromethyl-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-benzonitrile.

Provenance & Evidence