Trifluoroacetic acid → HCID 135926477, compound

Participants

Reaction Steps

560 mg [1-[3-Chloro-4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-carbamic acid tert-butyl ester were dissolved in 7 ml dichloromethane. 1 ml trifluoroacetic acid were added and the reaction mixture stirred at room temperature for one hour. The solvents were removed in vacuo and the residue purified by chromatography on reversed has to obtain 7 mg 3-{4-[4-Amino-6-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H-quinolin-1-yl]-2-chloro-phenyl}-4H-[1,2,4]oxadiazol-5-one.

Provenance & Evidence