HCID 67017328, compound → HCID 67017317, compound

Participants

Reaction Conditions

Reaction Steps

2.4 g (E)-3-[3-Amino-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-acrylic acid ethyl ester were dissolved in 50 ml tetrahydrofuran. 100 mg palladium on charcoil were added and the reaction mixture was stirred under an atmosphere of hydrogen at 40° C. for 4 hours. The cooled reaction mixture was filtered and the filtrate evaporated in vacuo to obtain 2.4 g 3-[3-Amino-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propionic acid ethyl ester.

Provenance & Evidence