Sodium ethoxide → HCID 67017331, compound

Participants

Reaction Steps

2.4 g 3-[3-Amino-6-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propionic acid ethyl ester were dissolved in 200 ml ethanol. 2.41 g sodium ethylate were added and the reaction mixture stirred at room temperature for ten minutes and then at 60° C. for 1.5 hours. The cooled reaction mixture was evaporated in vacuo and the residue dissolved in 100 ml ethyl acetate and 200 ml 4M HCl were added. The mixture was vigorously stirred at room temperature. The organic lay was separated and washed with 100 ml 4M HCl. The combined aqueous layers were neutralized with NaOH. The precipitate was filtered, washed with water and dried under vacuo to obtain 1.87 g 6-(4-Trifluoromethyl-phenyl)-3,4-dihydro-1H-[1,5]naphthyridin-2-one.

Provenance & Evidence