Hydrochloric Acid → HCID 67017324, compound

Participants

Reaction Conditions

Reaction Steps

710 mg 1-(4-Bromo-3-fluoro-benzenesulfonyl)-3,3-dimethyl-6-(4-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinoline and 123 mg copper(I)cyanide were dissolved in 1.5 ml dimethylformamide and heated to 200° C. under microwave irradiation for thirty minutes. The cooled reaction mixture was poured into 50 ml 2M hydrochloric acid and extracted five times with portions of 20 ml ethyl acetate. The combined organic layers were dried over MgSO4. The solvent was evaporated in vacuo and the residue purified by chromatography on silica gel to obtain 481 mg 4-[3,3-Dimethyl-6-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H-quinoline-1-sulfonyl]-2-fluoro-benzonitrile.

Provenance & Evidence