o-Fluorobenzaldehyde → HCID 56941067, compound

Participants

Reaction Steps

In a flask, dichloromethane (0.5 mL) and acetic acid (3drops) was added to N-(3-(pyridin-4-yl)-1H-indazol-5-yl)morpholine-2-carboxamide (0.014 g, 0.0443 mmol) and 2-fluorobenzaldehyde (0.0112 g, 0.09 mmol). The reaction was stirred for 15 minutes. Sodium triacetoxyborohydride (0.040 g, 0.177 mmol) was added in one portion. The reaction was stirred for an additional 16 hours. Saturated sodium bicarbarbonate (1 mL) was added. The reaction was stirred for an additional 5 minutes and was extracted with dichloromethane (3×1 mL). The extracts were combined, dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting crude product was purified by prep LC/MS. LC-MS: 432.2 [M+H]. LC/MS RT0.869 min.

Provenance & Evidence