(1-Bromoethyl)benzene → HCID 66608970, compound

HRID 1842050Notes

Reaction equation

HRID 1842050 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][C@H:3]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:2]1.Br[CH:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:16]>ClCCl>[C:17]1([CH:15]([N:1]2[CH2:6][CH2:5][CH2:4][C@H:3]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:2]2)[CH3:16])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 11454(1-Bromoethyl)benzeneHCID 1512710S-3-Piperidinecarboxylic acid1,1-dimethylethyl ester

Product 1

HCID 66608970HCID 66608970, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a flask, dichloromethane (0.432 mL) was added to (S)-tert-butyl piperidine-3-carboxylate (0.020 g, 0.108 mmol). At 0° C., (1-bromoethyl)benzene (0.030 g, 0.162 mmol) was added to the reaction. The solution was allowed to stir from 0° C. to room temperature for 3 hrs. The reaction was quenched using water (1 mL) and extracted using dichloromethane (3×1 mL). The extractions were combined and dried using sodium sulfate. The extracts were concentrated in vacuo, and the crude product was progressed to the next step without further purification.

Workup

  1. customThe reaction was quenched
  2. extractionextracted
  3. extractionThe extractions
  4. customdried
  5. concentrationThe extracts were concentrated in vacuo
  6. customthe crude product was progressed to the next step without further purification

Sources & evidence

ORD record
ord-d811dd5f20f942bca5eaa391f4c5f4cb
Source dataset
uspto-grants-2015_02
Patent number
US08946216B2

Reaction notes

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