HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fluorenylmethyloxycarbonyl isothiocyanate → 9H-fluoren-9-ylmethyl ({[(1S*,2R*,4R*)-1-(2-fluorophenyl)-2-(hydroxymethyl)-4-methoxycyclopentyl]amino}carbonothioyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fluorenylmethyloxycarbonyl isothiocyanate | HCID 22346806 | — |
| Reactant | [(1R*,2S*,4R*)-2-amino-2-(2-fluorophenyl)-4-methoxycyclopentyl]methanol | HCID 57827534 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 9H-fluoren-9-ylmethyl ({[(1S*,2R*,4R*)-1-(2-fluorophenyl)-2-(hydroxymethyl)-4-methoxycyclopentyl]amino}carbonothioyl)carbamate | HCID 57827571 | 62.5% |
Reaction Steps
A solution of [(1R*,2S*,4R*)-2-amino-2-(2-fluorophenyl)-4-methoxycyclopentyl]methanol (250 mg) and fluorenylmethyloxycarbonyl isothiocyanate (351 mg) in dichloromethane (20 mL) was stirred at room temperature for three days. The reaction solution was purified by silica gel column chromatography to obtain the title compound (340 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08946211B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-7a598f8a2ed34c95abb114188a949898 |
| Source note | uspto-grants-2015_02 |