HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1842316Generated: November 2, 2026
Hydrogen Peroxide → 1,1-Dimethylethyl 4-(2-amino-1,1-dimethyl-2-oxoethyl)-1-piperazinecarboxylate
https://huagongshe.com/reaction/1842316
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl 4-(2-cyanopropan-2-yl)piperazine-1-carboxylate | HCID 57420353 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1,1-Dimethylethyl 4-(2-amino-1,1-dimethyl-2-oxoethyl)-1-piperazinecarboxylate | HCID 57420354 | 309.7% |
Reaction Steps
To a cooled (ice/water bath) solution of 4-(cyano-dimethyl-methyl)-piperazine-1-carboxylic acid tert-butyl ester (102.9 mg) in dry DMSO was added K2CO3 (9.8 mg) followed by 28% hydrogen peroxide solution (200 μL) dropwise. The resultant was heated at 40° C. overnight. Water was added and the white solid collected, washed with water and air dried to give 4-(1-carbamoyl-1-methyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (59.6 mg). (See Tetrahedron 2002, 58, 3217). Treatment of this compound with HCl in DCM/MeOH yielded the desired amine, which was isolated as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08946217B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-c3990d6e972f493ba152772ff03d6b02 |
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| Source note | uspto-grants-2015_02 |
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